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Details

Stereochemistry ACHIRAL
Molecular Formula I
Molecular Weight 130.9061
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -1

SHOW SMILES / InChI
Structure of IODIDE ION I-131

SMILES

[131I-]

InChI

InChIKey=XMBWDFGMSWQBCA-RNFDNDRNSA-M
InChI=1S/HI/h1H/p-1/i1+4

HIDE SMILES / InChI
Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Therapeutic solutions of Sodium Iodide-131 are indicated for the treatment of hyperthyroidism and thyroid carcinomas that take up iodine. Palliative effects may be observed in patients with advanced thyroid malignancy if the metastatic lesions take up iodine. It is also indicated for use in performance of the radioactive iodide (RAI) uptake test to evaluate thyroid function. Taken orally, sodium iodide I-131 is rapidly absorbed and distributed within the extracellular fluid of the body. The iodide is concentrated in the thyroid via the sodium/iodide symporter, and subsequently oxidized to iodine. The destruction of thyroidal tissue is achieved by the beta emission of sodium iodide I-131.

Originator

Curator's Comment: Iodine-131 (131I) is an important radioisotope of iodine discovered by Glenn Seaborg and John Livingood in 1938 at the University of California, Berkeley.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
SODIUM IODIDE I 131

Approved Use

Sodium Iodide I 131 is indicated for the treatment of hyperthyroidism and thyroid carcinomas that take up iodide. Palliative effects may be observed in patients with advanced thyroid malignancy if the metastatic lesions take up iodide.

Launch Date

1971
Primary
SODIUM IODIDE I 131

Approved Use

Sodium Iodide I 131 is indicated for the treatment of hyperthyroidism and thyroid carcinomas that take up iodide. Palliative effects may be observed in patients with advanced thyroid malignancy if the metastatic lesions take up iodide.

Launch Date

1971

Sample Use Guides

The recommended dosage for orally administered Sodium Iodide I 131 Capsule USP is based on the thyroid gland uptake as well as the size of the gland. Thyroidal uptake and size should be determined by the physician prior to treatment and may be useful in calculating the therapeutic dose to be administered to the individual patient. Recommended dosages of orally administered Sodium Iodide I-131 are: Disease therapy: Antihyperthyroid Therapy: Oral dose of 148 to 370 megabecquerels (4 to 10 millicuries). Toxic nodular goiters and other serious thyroid conditions may require larger dosages. Antineoplastic – Ablation of normal thyroid tissue: Initial oral dose of 1.1 to 3.7 gigabecquerels (30 to 100 millicuries).Subsequent ablation of metastases with oral dose of 3.7 to 7.4 gigabecquerels (100 to 200 millicuries).
Route of Administration: Oral
Name Type Language
IODIDE ION I-131
Common Name English
IODIDE-131
Common Name English
IODIDE I-131 ION
Common Name English
IODIDE ION, I-131
Common Name English
IODIDE I-131
Common Name English
IODIDE ION I 131
Common Name English
RADIOIODINE
Common Name English
IODIDE (131I-)
Common Name English
Classification Tree Code System Code
NDF-RT N0000175872
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
NDF-RT N0000000205
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
WHO-ATC V09FX03
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
NCI_THESAURUS C799
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
Code System Code Type Description
FDA UNII
4GC1FOQ22U
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
DAILYMED
4GC1FOQ22U
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
EPA CompTox
DTXSID70933558
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
RXCUI
1546415
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY RxNorm
CAS
14914-30-8
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
DRUG BANK
DB09293
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
NCI_THESAURUS
C87413
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
PUBCHEM
167195
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY